![]() ![]() JUUL delivers substantially more nicotine to the blood per puff than cigarettes or previous-generation e-cigarettes (e-cigs) and impairs blood vessel function comparable to cigarette smoke, according to a new study by researchers at UC San Francisco. JUUL Also Impairs Blood Vessel Function Similar to Cigarette Smoke, UCSF Researchers Find | Delivers Substantially More Nicotine than Previous Generation E-Cigs and Cigarettes Here is the UCSF press release on the paper: JUUL and Combusted Cigarettes Comparably Impair Endothelial Function. The full citation is: Rao P, Liu J, Springer M. JUUL and previous generation e-cigs impairs endothelial function in rats, comparable to impairment by cigarette smoke. Nicotine was highest in serum from the JUUL group for the other e-cig and cigarette groups, nicotine levels were lower and comparable to each other. The extent of impairment ranged from 34% to 58%, although the differences between groups were not statistically significant. Results: Aerosol/smoke from JUUL, previous generation e-cigs, and cigarettes all impaired endothelial function. Blood was collected 20 minutes post-exposure for serum nicotine analysis. We measured endothelial function pre- and post-exposure. Methods: We exposed rats to aerosol from Virginia Tobacco flavor JUUL, an e-cig tank system using unflavored free-base nicotine e-liquid, Marlboro Red combustible tobacco cigarettes, or clean air for 10 cycles of 2 second inhalation over 5 minutes. We investigated whether exposure to JUUL and previous generation e-cig aerosol impairs endothelial function comparably to cigarette smoke. JUUL Labs, in particular, claims that switching from smoking to vaping has beneficial impacts however, the health effects of such products are not well understood. Objectives: JUUL and earlier generation electronic cigarettes (e-cigs) are promoted as being less hazardous than cigarettes. The graph below (taken from Figure 3 of the paper) shows the similarities in how these three tobacco products reduce FMD:Į-cigarette apologists will no doubt criticize this paper because it was a study of rats not people, but the reality is that this animal experimental model is well-established.Īnother important fact: The study used Juul Virginia Tobacco flavor the new FDA enforcement policy also exempts tobacco flavor. Impairment of this so-called flow mediated dilation (FMD) makes impaired functioning of the cardiovascular system and predicts future heart attack risk. They compared to Juul, a third generation tank system e-cigarette ( the kind FDA is giving a pass in its enforcement against some e-cig flavors), and a Marlboro Red cigarette against clean air affect arteries’ ability to dilate (get larger) in the face of increased demands for blood flow. My colleagues Poonam Rao, Jiangtao Liu, and Matt Springer just published “ JUUL and Combusted Cigarettes Comparably Impair Endothelial Function” in Tobacco Regulatory Science. ![]()
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